College Football Week 11 Preview: Indiana Hosts USC in Big Ten Showdown

The Week 11 college football schedule is headlined by a marquee Big Ten clash, with No. 9 Indiana hosting No. 18 USC on Saturday at 3:30 p.m. ET on CBS. The Hoosiers, the defending national champions whose only loss came against Ohio State, are 7.5-point favorites with an over/under of 49.5. USC arrives well rested after an emphatic win over the Buckeyes followed by a bye, while coach Curt Cignetti's squad is seeking a signature victory after a light non-conference schedule.

The weekend opens Friday night when Florida State visits Pittsburgh at 7 p.m. ET. The Seminoles fired coach Mike Norvell after a 36-24 loss to Clemson two weeks ago and beat Boston College 31-24 under interim coach Rick Stockstill. Florida State (4-5) still needs two wins to reach bowl eligibility, while Pitt (6-3) is already bowl eligible after a 34-11 win over Georgia Tech snapped a three-game skid. The Panthers are 3.5-point home favorites, and the over/under is 54.5.

No. 4 UCLA, one of only two remaining unbeaten teams in the FBS at 9-0, hosts Illinois at 9 p.m. ET Friday. Backup quarterback Ty Dieffenbach owns a higher passer rating (142.9) than the injured Nico Iamaleava (138.1), but the Illini have won four straight after a 2-3 start and remain in the Big Ten title mix at 4-2 in league play. UCLA is favored by 10 with a total of 46.5. In the late window, Colorado hosts No. 14 Houston at 10:15 p.m. ET. The Buffaloes are 3-6 and have lost 17 of their last 24 games under Deion Sanders, while the Cougars are 7-2 and favored by 10, with an over/under of 50.5.

Saturday's noon window features No. 7 Miami hosting Duke. The Hurricanes are coming off their first loss of the season and are still adjusting with star receiver Malachi Toney sidelined by an ankle injury. Duke, last year's ACC champion, has outscored opponents 88-5 over the past two weeks, and coach Manny Diaz faces his former team. Miami is a 13.5-point favorite with a total of 54.5. In Dallas, No. 13 Wake Forest visits SMU with both teams in the ACC title hunt. The Demon Deacons (8-1) are 1.5-point road favorites over the Mustangs (7-2), and the over/under is 61.5, with Kevin Jennings and Gio Lopez among the most experienced quarterbacks in the nation.

No. 20 Ohio State also hosts Northwestern at noon. The Buckeyes (6-3) have dropped back-to-back games to USC and Oregon since losing quarterback Julian Sayin, surrendering 71 points in those defeats. Northwestern (6-3) has lost two straight of its own and has not won at Ohio Stadium since 1971. Ohio State is a 12.5-point favorite, and the over/under is 47.5.

At 3 p.m. ET Saturday, No. 8 Tennessee visits Texas A&M. The Volunteers (7-2) remain squarely in the College Football Playoff race, while the Aggies have slid to 4-5 a season after reaching the CFP. Tennessee is a 2.5-point road favorite with a total of 42.5. At 3:30 p.m. ET, new No. 1 Georgia hosts No. 22 Missouri fresh off a 42-7 rout of Ole Miss. The Tigers (6-3) are coming off a loss to Texas that likely ended their SEC and playoff hopes. Georgia is a 15.5-point favorite, and the over/under is 47.5.

The evening slate opens with No. 11 Kentucky hosting Florida at 6:15 p.m. ET. The Wildcats were routed by Tennessee last week but remain in the SEC and playoff picture, while Florida has lost four of five, each defeat by double digits. Kentucky is favored by 3.5 with a total of 51.5.

In the 7:30 p.m. ET window, No. 6 Texas visits No. 21 LSU, where Lane Kiffin is coaching his first season. The Longhorns won 34-20 at Missouri last week, yet the Tigers are 3.5-point home favorites with a 46.5 total. At the same time, No. 2 Utah puts its 15-game winning streak on the line at No. 23 Arizona. Devon Dampier accounted for four touchdowns in last week's win over rival BYU, while Arizona's Noah Fifita is chasing a Heisman moment. Utah is a 2.5-point road favorite, and the over/under is 53.5.

The night closes with No. 25 Oklahoma State hosting No. 12 Texas Tech at 9:30 p.m. ET. Cowboys quarterback Drew Mestemaker, a former high school backup who walked on at North Texas, has authored one of the sport's most improbable rise stories, while the Red Raiders are chasing a second straight CFP berth. Despite the ranking gap, Oklahoma State is a 3.5-point home favorite, and the over/under is a lofty 72.5.